Tumor-draining lymph nodes: At the crossroads of metastasis and immunity
Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance
Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
S García-Silva, A Benito-Martín, L Nogués… - Nature Cancer, 2021 - nature.com
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
Targeting immunosuppressive adenosine in cancer
Despite the success of anti-programmed cell death protein 1 (PD1), anti-PD1 ligand 1
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
Material design for lymph node drug delivery
A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …
Fluids and their mechanics in tumour transit: shaping metastasis
Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …
distant sites within the body, ultimately reducing the survival of patients with cancer. To …
Extracellular vesicle–matrix interactions
The extracellular matrix (ECM) harbours various signals to control cellular functions and the
materiality of tissues. Most efforts to synthetically reconstitute the matrix by biomaterial …
materiality of tissues. Most efforts to synthetically reconstitute the matrix by biomaterial …
[HTML][HTML] Lymphatic vessel network structure and physiology
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …
which has the holistic function to maintain the local physiologic environment for every cell in …
[HTML][HTML] Unlocking the power of exosomes for crossing biological barriers in drug delivery
RO Elliott, M He - Pharmaceutics, 2021 - mdpi.com
Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …
of nanovesicles called exosomes has been driving the research field to a new regime for …
Lymphatic vessels in cancer
The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …
nodes that are present in almost every tissue of the human body, acts as an essential …