In response to mechanical forces and the aging process, bone in the adult skeleton is
continuously remodeled by a process in which old and damaged bone is removed by bone …

Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …

Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Outcomes after tendon repair are often unsatisfactory, despite improvements in surgical
techniques and rehabilitation methods. Recent studies aimed at enhancing repair have …

Parathyroid hormone (PTH) stimulates bone remodeling and induces differentiation of bone
marrow mesenchymal stromal/stem cells (MSCs) by orchestrating activities of local factors …

Osteoporosis is a reduction in skeletal mass due to an imbalance between bone formation
and bone resorption. Many researchers have tried to develop adjuvants as specific …

Differentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of
bone development and homeostasis, and may when improperly regulated cause disease …

The osteogenic effects of Bone Morphogenetic Proteins (BMPs) were delineated in 1965
when Urist et al. showed that BMPs could induce ectopic bone formation. In subsequent …

Background Bone tissue engineering and the research surrounding peptides has expanded
significantly over the last few decades. Several peptides have been shown to support and …

Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell
types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells …