Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies
including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases …

Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of developing
several of the major health issues facing the western world, including neurodegenerative …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

We describe a second primase in human cells, PrimPol, which has the ability to start DNA
chains with deoxynucleotides unlike regular primases, which use exclusively …

The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …