Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …

Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …

Many conventional chemotherapies used in cancer treatment exert their effect by inflicting
DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable …

The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2
(CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase …

Introduction: Quantitative structure–activity relationship (QSAR) modeling is one of the most
popular computer-aided tools employed in medicinal chemistry for drug discovery and lead …

Simple Summary The DNA damage response pathway plays a critical role in maintaining
genomic integrity. Therefore, inhibition of activation of cell-cycle checkpoints involved in this …

DNA inevitably undergoes a high number of damages throughout the cell cycle. To preserve
the integrity of the genome, cells have developed a complex enzymatic machinery aimed at …

Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …