The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric
entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …

It is now generally accepted that G protein-coupled receptors (GPCRs) can exist as dimers
or as part of larger oligomeric complexes. Increasing evidence suggests that a dimer is the …

P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been
recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this …

The complement system is a crucial component of the host response to infection and tissue
damage. Activation of the complement cascade generates anaphylatoxins including C5a …

Complement factor C5a is an integral constituent of the complement cascade critically
involved in the innate immune response, and it exerts its functions via two distinct receptors …

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane
receptors and are responsible for transducing extracellular signals into intracellular …

The anaphylatoxins (AT) C3a and C5a play important roles as mediators of inflammation.
Further, they regulate and control multiple innate and adaptive immune responses through …

The higher-order structure of G protein-coupled receptors (GPCRs) in membranes may
involve dimerization and formation of even larger oligomeric complexes. Here, we have …

Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of
a gradient of locally produced chemotactic factors. This review is focused on current …