Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Immune interventions in stroke

Y Fu, Q Liu, J Anrather, FD Shi - Nature Reviews Neurology, 2015 - nature.com
Approaches for the effective management of acute stroke are sparse, and many measures
for brain protection fail. However, our ability to modulate the immune system and modify the …

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a …

B Leonard, M Maes - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

R Jin, G Yang, G Li - Journal of leukocyte biology, 2010 - academic.oup.com
Review on the time-dependent recruitment of inflammatory cells and unanswered questions
regarding inflammatory cells in the pathophysiology of ischemic stroke. Inflammation plays …

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

S Moylan, M Maes, NR Wray, M Berk - Molecular psychiatry, 2013 - nature.com
In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

M Gelderblom, A Weymar… - Blood, The Journal …, 2012 - ashpublications.org
The devastating effect of ischemic stroke is attenuated in mice lacking conventional and
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

T Shichita, Y Sugiyama, H Ooboshi, H Sugimori… - Nature medicine, 2009 - nature.com
Lymphocyte recruitment and activation have been implicated in the progression of cerebral
ischemia-reperfusion (I/R) injury, but the roles of specific lymphocyte subpopulations and …

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

A Liesz, E Suri-Payer, C Veltkamp, H Doerr… - Nature medicine, 2009 - nature.com
Systemic and local inflammatory processes have a key, mainly detrimental role in the
pathophysiology of ischemic stroke. Currently, little is known about endogenous …

Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?

R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

The immune system's role in the biology of autism

P Goines, J Van de Water - Current opinion in neurology, 2010 - journals.lww.com
The immune system's role in the biology of autism : Current Opinion in Neurology The immune
system's role in the biology of autism : Current Opinion in Neurology Log in or Register …