Pulmonary drug delivery is relatively complex because the respiratory tract has evolved
defense mechanisms to keep inhaled drug particles out of the lungs and to remove or …

Leucine is a promising excipient with several applications in the development of inhalable
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …

Purpose: The increasing burden of invasive fungal infections results in growing challenges
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …

The aim of this study is to investigate the influence of excipients on physical and
aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The …

The repurposing of drug delivery by the pulmonary route has been applied to treatment and
prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been …

Purpose Inhalation therapy is popular to treat lower respiratory tract infections. Azithromycin
is effective against some bacteria that cause respiratory tract infections; but it has poor water …

Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can
likely be enhanced through mucosal immunization induced by direct delivery of vaccines to …

Introduction Disease due to pulmonary infection with Aspergillus, and other emerging
opportunistic fungi remains a significant unmet need. Existing antifungal medicines are …

Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is
limited by the poor lung deposition and severe adverse effects. In contrast, pulmonary …

Pulmonary delivery of short interfering RNA (siRNA) has been widely studied in both animal
and clinical studies to treat various respiratory diseases by gene silencing through RNA …