Despite recent successful efforts to reduce the global malaria burden, this disease remains a
significant global health problem. Only in 2018, malaria caused 228 million clinical …

Importance Malaria is caused by protozoa parasites of the genusPlasmodiumand is
diagnosed in approximately 2000 people in the US each year who have returned from …

Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …

Malaria affected an estimated 216 million people causing 445,000 deaths in 2016. 1 This
reduced burden of disease and death is a result of more than a century of worldwide effort …

Malaria remains of significant public health concern under the tropics, causing millions of
deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which …

Cerebral malaria is a lethal complication of malaria infection characterized by central
nervous system dysfunction and is often not effectively treated by antimalarial combination …

Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …

During severe malaria, both in endemic and non-endemic areas, cerebral malaria is strongly
associated with mortality and morbidity. The main mechanisms of cerebral malaria combine …

Despite advances in our understanding of malarial pathogenesis much remains unknown.
Antimalarial agents eradicate parasites but no treatments are available to prevent or …

Typical of tropical and subtropical regions, malaria is caused by protozoa of the genus
Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a …