Aberrant gene expression that drives human cancer can arise from epigenetic
dysregulation. Although much attention has focused on altered activity of transcription …

The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense” …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …

Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

Background Chemoresistance to cisplatin (DDP) remains a major challenge in advanced
gastric cancer (GC) treatment. Although accumulating evidence suggests an association …

Reprogrammed cellular metabolism is a common characteristic observed in various
cancers,. However, whether metabolic changes directly regulate cancer development and …

Autophagy is a catabolic pathway by which cellular components are delivered to the
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Limited knowledge of the mechanisms that govern the self-renewal of human
haematopoietic stem cells (HSCs), and why this fails in culture, have impeded the expansion …