A guide to artificial intelligence for cancer researchers

R Perez-Lopez, N Ghaffari Laleh, F Mahmood… - Nature Reviews …, 2024 - nature.com
Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to
a readily accessible tool for cancer researchers. AI-based tools can boost research …

Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions

W Lotter, MJ Hassett, N Schultz, KL Kehl, EM Van Allen… - Cancer Discovery, 2024 - AACR
Artificial intelligence (AI) in oncology is advancing beyond algorithm development to
integration into clinical practice. This review describes the current state of the field, with a …

Privacy-preserving large language models for structured medical information retrieval

IC Wiest, D Ferber, J Zhu, M van Treeck, SK Meyer… - NPJ Digital …, 2024 - nature.com
Most clinical information is encoded as free text, not accessible for quantitative analysis. This
study presents an open-source pipeline using the local large language model (LLM)“Llama …

Large language model use in clinical oncology

N Carl, F Schramm, S Haggenmüller, JN Kather… - NPJ Precision …, 2024 - nature.com
Large language models (LLMs) are undergoing intensive research for various healthcare
domains. This systematic review and meta-analysis assesses current applications …

From text to tables: a local privacy preserving large language model for structured information retrieval from medical documents

IC Wiest, D Ferber, J Zhu, M van Treeck, SK Meyer… - MedRxiv, 2023 - medrxiv.org
Abstract Background and Aims Most clinical information is encoded as text, but extracting
quantitative information from text is challenging. Large Language Models (LLMs) have …

[HTML][HTML] The ESMO Tumour-Agnostic Classifier and Screener (ETAC-S): a tool for assessing tumour-agnostic potential of molecularly guided therapies and for steering …

CB Westphalen, D Martins-Branco, JR Beal… - Annals of …, 2024 - Elsevier
Background Advances in precision oncology led to approval of tumour-agnostic molecularly
guided treatment options (MGTOs). The minimum requirements for claiming tumour-agnostic …

[HTML][HTML] Real-world outcomes of treatment strategy between first-line osimertinib, first/second-generation EGFR-TKIs followed by osimertinib and without osimertinib in …

Y Uehara, Y Takeyasu, T Yoshida, A Tateishi… - ESMO Real World Data …, 2024 - Elsevier
Background Osimertinib has been the standard of care in epidermal growth factor receptor
(EGFR)-mutant non-small-cell lung cancer (NSCLC). We evaluated outcomes between …

Generating and using real-world data: A worthwhile uphill battle

K Verkerk, EE Voest - Cell, 2024 - cell.com
The precision oncology paradigm challenges the feasibility and data generalizability of
traditional clinical trials. Consequently, an unmet need exists for practical approaches to test …

[HTML][HTML] Atezolizumab/bevacizumab or lenvatinib in hepatocellular carcinoma: Multicenter real-world study with focus on bleeding and thromboembolic events

NB Khaled, M Möller, LS Jochheim, C Leyh, U Ehmer… - JHEP Reports, 2024 - Elsevier
Background & Aims Atezolizumab/bevacizumab (atezo/bev) and lenvatinib have
demonstrated efficacy as first-line therapies for hepatocellular carcinoma (HCC). However …

[HTML][HTML] The impact of inter-cycle treatment delays on 5-year all-cause mortality in early-stage breast cancer: A retrospective cohort study

L Steventon, E Kipps, KKC Man, R Roylance… - European Journal of …, 2024 - Elsevier
Background Inter-cycle delays to chemotherapy are often required to manage drug toxicity.
The impact of delays on mortality is poorly characterised. This retrospective cohort study …