SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
E Ferrannini, A Solini - Nature Reviews Endocrinology, 2012 - nature.com
This Review covers the rationale, physiological consequences and clinical application of
pharmacological sodium–glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 …
pharmacological sodium–glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 …
Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study
R Nahra, T Wang, KM Gadde, J Oscarsson… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Cotadutide, a dual GLP-1 and glucagon receptor agonist, is under development
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …
The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review
DC Llewellyn, H Logan Ellis, SJB Aylwin, E Oštarijaš… - …, 2023 - Wiley Online Library
Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an
increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve …
increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve …
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending …
P Ambery, VE Parker, M Stumvoll, MG Posch, T Heise… - The Lancet, 2018 - thelancet.com
Background Weight loss is often key in the management of obese or overweight patients
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …
Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross‐national benchmarking of diabetes‐related psychosocial outcomes for people with diabetes
A Nicolucci, K Kovacs Burns, RIG Holt… - Diabetic …, 2013 - Wiley Online Library
Abstract Aims The second Diabetes Attitudes, Wishes and Needs (DAWN 2) study aimed to
assess psychosocial outcomes in people with diabetes across countries for benchmarking …
assess psychosocial outcomes in people with diabetes across countries for benchmarking …
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
OBJECTIVE To investigate the efficacy and tolerability of empagliflozin as an add-on to
metformin therapy in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS …
metformin therapy in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS …
Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity
Y Si, Y Zhao, H Hao, J Liu, Y Guo, Y Mu, J Shen… - Diabetes, 2012 - Am Diabetes Assoc
Infusion of mesenchymal stem cells (MSCs) has been shown to effectively lower blood
glucose in diabetic individuals, but the mechanism involved could not be adequately …
glucose in diabetic individuals, but the mechanism involved could not be adequately …
[HTML][HTML] High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal
DA Magalhães, WT Kume, FS Correia… - Anais da Academia …, 2019 - SciELO Brasil
Our objective was to establish a diabetes mellitus type 2 (DM2) model in rats using a high-fat
diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control …
diet and streptozotocin (HF-STZ). Male Wistar rats (240-250g) were divided into a control …
Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
T Heise, E Seewaldt‐Becker, S Macha… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aim To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of
empagliflozin in patients with type 2 diabetes following oral administration of 10, 25 or 100 …
empagliflozin in patients with type 2 diabetes following oral administration of 10, 25 or 100 …
Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats
BK Ramadan, MF Schaalan, AM Tolba - BMC complementary and …, 2017 - Springer
Background Diabetes is a major public health concern. In spite of continuous new drug
development to treat diabetes, herbal remedies remain a potential adjunct therapy to …
development to treat diabetes, herbal remedies remain a potential adjunct therapy to …