Are cancer cells really softer than normal cells?

C Alibert, B Goud, JB Manneville - Biology of the Cell, 2017 - Wiley Online Library
Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

Mechanical properties of single cells: Measurement methods and applications

Y Hao, S Cheng, Y Tanaka, Y Hosokawa… - Biotechnology …, 2020 - Elsevier
Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

Dynamic magneto-softening of 3D hydrogel reverses malignant transformation of cancer cells and enhances drug efficacy

Y Shou, XY Teo, X Li, L Zhicheng, L Liu, X Sun… - ACS …, 2023 - ACS Publications
High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …

Ratiometric near-infrared fluorescence nanothermometry in the OTN-NIR (NIR II/III) biological window based on rare-earth doped β-NaYF 4 nanoparticles

M Kamimura, T Matsumoto, S Suyari… - Journal of Materials …, 2017 - pubs.rsc.org
A novel nanothermometer based on over-1000 nm (OTN) near-infrared (NIR) emission of
rare-earth doped ceramic nanophosphors (RED-CNPs) was developed for temperature …

Simultaneous nanorheometry and nanothermometry using intracellular diamond quantum sensors

Q Gu, L Shanahan, JW Hart, S Belser, N Shofer… - ACS …, 2023 - ACS Publications
The viscoelasticity of the cytoplasm plays a critical role in cell morphology, cell division, and
intracellular transport. Viscoelasticity is also interconnected with other biophysical …

Viscoelasticity, like forces, plays a role in mechanotransduction

CT Mierke - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Myosin II activity softens cells in suspension

CJ Chan, AE Ekpenyong, S Golfier, W Li, KJ Chalut… - Biophysical journal, 2015 - cell.com
The cellular cytoskeleton is crucial for many cellular functions such as cell motility and
wound healing, as well as other processes that require shape change or force generation …

Microfluidic deformability cytometry: A review

Y Chen, K Guo, L Jiang, S Zhu, Z Ni, N Xiang - Talanta, 2023 - Elsevier
Cell deformability plays an important role in cellular processes and functions, including cell
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …

Actin and microtubule networks contribute differently to cell response for small and large strains

H Kubitschke, J Schnauß, KD Nnetu… - New Journal of …, 2017 - iopscience.iop.org
Cytoskeletal filaments provide cells with mechanical stability and organization. The main key
players are actin filaments and microtubules governing a cell's response to mechanical …

One-dimensional ZnO/gold junction for simultaneous and versatile multisensing measurements

B Miccoli, V Cauda, A Bonanno, A Sanginario… - Scientific reports, 2016 - nature.com
The sensing capabilities of zinc oxide nano/micro-structures have been widely investigated
and these structures are frequently used in the fabrication of cutting-edge sensors. However …