Insulin-like growth factor 1 (IGF1) is a polypeptide hormone structurally similar to insulin. It is
central to the somatotropic axis, acting downstream of growth hormone (GH). It activates …

The concept that growth hormone and IGF-1 are required for normal development of the
mammalian body and, more recently the brain, is supported by a vast experimental …

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates the adaptive
response to hypoxia in mammalian cells. It consists of a regulatory subunit HIF-1α, which …

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1,
provides a landscape of molecular mechanisms involved in cardiovascular alterations in …

Insulin-like growth factor-1 (IGF-1) is a naturally occurring neurotrophic factor that plays an
important role in promoting cell proliferation and differentiation during normal brain …

Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with
age. In the past two decades, extensive research has determined that the reduction in IGF-1 …

Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …

Therapeutic hypothermia is now proven to reduce death or disability in term and near‐term
born infants with moderate to severe hypoxic‐ischemic encephalopathy. Nevertheless …

In studies of transgenic (Tg) mice that overexpress insulin-like growth factor-I (IGF-I)
exclusively in the CNS, we demonstrated a dramatic increase in cerebellar granule cell …

Schizophrenia etiology is thought to involve an interaction between genetic and
environmental factors during postnatal brain development. However, there is a fundamental …