Impact of the Human Cell Atlas on medicine
JE Rood, A Maartens, A Hupalowska, SA Teichmann… - Nature medicine, 2022 - nature.com
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Epigenetic regulation of T cell exhaustion
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …
which is characterized by reduced effector function and proliferation, and the expression of …
Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …
connections between genes, which impedes discoveries in settings with limited data …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Mapping single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
Mapping the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of …
understanding tissue dynamics in health and disease. We lack a comprehensive map of …
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
The human lung differs substantially from its mouse counterpart, resulting in a distinct distal
airway architecture affected by disease pathology in chronic obstructive pulmonary disease …
airway architecture affected by disease pathology in chronic obstructive pulmonary disease …
SARS-CoV-2 infection of the oral cavity and saliva
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
E Madissoon, AJ Oliver, V Kleshchevnikov… - Nature Genetics, 2023 - nature.com
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …