Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the
immune system. The list of target antigens in this disease is ever increasing and it is …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

According to the quality of response they mediate, autoreactive T cells recognizing islet β
cell peptides could represent both disease effectors in the development of type 1 diabetes …

On induction of cell differentiation, distinct cell phenotypes are encoded by complex genetic
networks,,. These networks can prevent the reversion of established phenotypes even in the …

In autoimmune type 1 diabetes, pathogenic T lymphocytes are associated with the specific
destruction of insulin-producing β-islet cells,. Identification of the autoantigens involved in …

Summary Type I diabetes (T1D) is a T cell-mediated autoimmune disease characterized by
loss of tolerance to islet autoantigens, leading to the destruction of insulin-producing beta …

Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells,
detection of these rare lymphocytes remains largely elusive. Suitable T-cell assays are …

Accumulating lines of evidence have suggested that regulatory T cells (Tregs) play a central
role in T cell-mediated immune response and the development of type 1A and fulminant type …

OBJECTIVE Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key
mechanism in the maintenance of self-tolerance and protection from type 1 diabetes. To …

It is widely accepted that Type 1 diabetes is a complex disease. Genetic predisposition and
environmental factors favour the triggering of autoimmune responses against pancreatic β …