Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

A review on comparative studies addressing exosome isolation methods from body fluids

TS Martins, M Vaz, AG Henriques - Analytical and Bioanalytical Chemistry, 2023 - Springer
Exosomes emerged as valuable sources of disease biomarkers and new therapeutic tools.
However, extracellular vesicles isolation with exosome-like characteristics from certain …

Recent progresses in exosome-based systems for targeted drug delivery to the brain

S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

A Rai, H Fang, B Claridge, RJ Simpson… - Journal of …, 2021 - Wiley Online Library
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

Exosomes: potential disease biomarkers and new therapeutic targets

MI Mosquera-Heredia, LC Morales, OM Vidal… - Biomedicines, 2021 - mdpi.com
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …

Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro

L Garaeva, R Kamyshinsky, Y Kil, E Varfolomeeva… - Scientific reports, 2021 - nature.com
Plant-derived extracellular vesicles (EVs) gain more and more attention as promising
carriers of exogenous bioactive molecules to the human cells. Derived from various edible …

Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment

A Srivastava, S Rathore, A Munshi… - Seminars in cancer biology, 2022 - Elsevier
Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles
produced by the cells, among which exosomes form the largest group. Exosomes perform …

Extracellular vesicles in fungi: past, present, and future perspectives

J Rizzo, ML Rodrigues, G Janbon - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical
research fields. Many studies have reported the existence of EVs in all types of living cells …

Upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles

G Huang, Y Liu, D Wang, Y Zhu, S Wen, J Ruan, D Jin - ELight, 2022 - Springer
Although small EVs (sEVs) have been used widely as biomarkers in disease diagnosis, their
heterogeneity at single EV level has rarely been revealed. This is because high-resolution …

Unraveling multilayered extracellular vesicles: Speculation on cause

K Broad, SA Walker, I Davidovich… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play
important roles in (patho) physiological processes through intercellular communication. EVs …