Progress in the mechanism and targeted drug therapy for COPD

C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation

BM Fischer, E Pavlisko, JA Voynow - International journal of chronic …, 2011 - Taylor & Francis
Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of
chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow …

IL-33 mediated inflammation in chronic respiratory diseases—understanding the role of the member of IL-1 superfamily

A Gabryelska, P Kuna, A Antczak… - Frontiers in …, 2019 - frontiersin.org
Interleukin 33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 is localized in the
nucleus and acts there as a gene regulator. Following injury, stress or cell death, it is …

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

S Hobbins, ILC Chapple, E Sapey… - International journal of …, 2017 - Taylor & Francis
COPD is recognized as having a series of comorbidities potentially related to common
inflammatory processes. Periodontitis is one of the most common human inflammatory …

Pulmonary biomarkers in chronic obstructive pulmonary disease

PJ Barnes, B Chowdhury, SA Kharitonov… - American journal of …, 2006 - atsjournals.org
There has been increasing interest in using pulmonary biomarkers to understand and
monitor the inflammation in the respiratory tract of patients with chronic obstructive …

Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function

WA Neveu, JL Allard, DM Raymond, LM Bourassa… - Respiratory …, 2010 - Springer
Background Asthma is a chronic inflammatory disease of the airway that is characterized by
a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The …

Engineering a point-of-care paper-microfluidic electrochemical device applied to the multiplexed quantitative detection of biomarkers in sputum

M Gutiérrez-Capitán, A Sanchís, EO Carvalho… - ACS …, 2023 - ACS Publications
Health initiatives worldwide demand affordable point-of-care devices to aid in the reduction
of morbidity and mortality rates of high-incidence infectious and noncommunicable …

Differences in cytotoxicity versus pro-inflammatory potency of different PM fractions in human epithelial lung cells

M Gualtieri, J Øvrevik, JA Holme, MG Perrone… - Toxicology in vitro, 2010 - Elsevier
Air pollution in Milan causes health concern due to the high concentrations of particulate
matter (PM10 and PM2. 5). The aim of this study was to investigate possible seasonal …

Pathophysiology of exacerbations of chronic obstructive pulmonary disease

A Papi, F Luppi, F Franco, LM Fabbri - Proceedings of the American …, 2006 - atsjournals.org
Smokers with stable chronic obstructive pulmonary disease have a chronic inflammation of
the entire tracheobronchial tree characterized by an increased number of macrophages and …

The neutrophil in chronic obstructive pulmonary disease

JK Quint, JA Wedzicha - Journal of allergy and clinical immunology, 2007 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous collection of
conditions characterized by irreversible expiratory airflow limitation. The disease involves a …