RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

Development of fluorescence polarization (FP) assays, especially in a competitive manner,
is a potent and mature tool for measuring the binding affinities of small molecules. This …

Inhibition of the RNA-binding protein LIN28 and disruption of the protein–RNA interaction of
LIN28–let-7 with small molecules holds great potential to develop new anticancer …

CUGBP Elav-like family member 1 (CELF1), an RNA-binding protein (RBP), plays important
roles in the pathogenesis of diseases such as myotonic dystrophy, liver fibrosis and cancers …

Targeting RNA-binding and modifying proteins via small molecules to modulate post-
transcriptional modifications have emerged as a new frontier for chemical biology and …

In recent years, RNA has gained traction both as a therapeutic molecule and as a
therapeutic target in several human pathologies. In this review, we consider the approach of …

In recent years, advances in biomedicine have revealed an important role for post-
transcriptional mechanisms of gene expression regulation in pathologic conditions. In …

Small‐molecule inhibitors of the RNA‐binding and regulating protein LIN28 have the
potential to be developed as chemical probes for biological perturbation and as therapeutic …

Breast cancer is the most common malignancy in women and has a high incidence rate and
mortality. Abnormal regulation of gene expression plays an important role in breast cancer …

The RNA-binding protein LIN28 is a regulator of miRNA let-7 biogenesis. Inhibitors of LIN28
are highly sought after given the central role that LIN28 plays in tumorigenesis and …