Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …

Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

Microfluidics permit the automated manipulation of fluids at the microscale with high
throughput and spatiotemporal precision, enabling the generation of large, multidimensional …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

In the last decade, different research groups in the academic setting have developed
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …

Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting …

Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid
technology with the power of artificial intelligence. Organoids, three-dimensional miniature …

Human organoids stand at the forefront of basic and translational research, providing
experimentally tractable systems to study human development and disease. These stem cell …

Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …