Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …
However, developing drugs for central nervous system (CNS) disorders remains the most …
[HTML][HTML] AI-enabled organoids: construction, analysis, and application
L Bai, Y Wu, G Li, W Zhang, H Zhang, J Su - Bioactive Materials, 2024 - Elsevier
Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …
function of organs, have attracted considerable interest due to their promising applications in …
[HTML][HTML] Intelligent microfluidics: The convergence of machine learning and microfluidics in materials science and biomedicine
Microfluidics permit the automated manipulation of fluids at the microscale with high
throughput and spatiotemporal precision, enabling the generation of large, multidimensional …
throughput and spatiotemporal precision, enabling the generation of large, multidimensional …
[HTML][HTML] 3D and organoid culture in research: physiology, hereditary genetic diseases and cancer
E Suarez-Martinez, I Suazo-Sanchez, M Celis-Romero… - Cell & Bioscience, 2022 - Springer
In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …
extracellular molecules and niche soluble and mechanical signaling. These …
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
R Xie, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2023 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
[HTML][HTML] Advancing drug discovery for neurological disorders using iPSC-derived neural organoids
G Costamagna, GP Comi, S Corti - International Journal of Molecular …, 2021 - mdpi.com
In the last decade, different research groups in the academic setting have developed
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
[HTML][HTML] Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls
A Di Credico, A Weiss, M Corsini, G Gaggi… - Scientific Reports, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting …
characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting …
[HTML][HTML] Organoid intelligence: Integration of organoid technology and artificial intelligence in the new era of in vitro models
H Shi, A Kowalczewski, D Vu, X Liu, A Salekin… - Medicine in novel …, 2024 - Elsevier
Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid
technology with the power of artificial intelligence. Organoids, three-dimensional miniature …
technology with the power of artificial intelligence. Organoids, three-dimensional miniature …
[HTML][HTML] Human neural organoids: Models for developmental neurobiology and disease
Human organoids stand at the forefront of basic and translational research, providing
experimentally tractable systems to study human development and disease. These stem cell …
experimentally tractable systems to study human development and disease. These stem cell …
[HTML][HTML] Patient-derived midbrain organoids to explore the molecular basis of Parkinson's disease
B Galet, H Cheval, P Ravassard - Frontiers in Neurology, 2020 - frontiersin.org
Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …
human tissues that recapitulate features of architecture, composition and function of in vivo …