Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I
molecules with endogenous peptides during their biosynthesis within the endoplasmic …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Trained innate immunity, induced via modulation of mature myeloid cells or their bone
marrow progenitors, mediates sustained increased responsiveness to secondary …

Until recently, hematopoietic stem cell transplantation was the only curative option for
Wiskott-Aldrich syndrome (WAS). The first attempts at gene therapy for WAS using a ϒ …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …

The immune system is a fundamental part of the tumor microenvironment. In particular,
cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth …

Modified or misplaced DNA can be recognized as a danger signal by mammalian cells.
Activation of cellular responses to DNA has evolved as a defense mechanism to microbial …

RAC2 is a GTPase that is exclusively expressed in hematopoietic cells. Animal models have
suggested important roles for RAC2 in the biology of different cell types, such as neutrophils …

Background Dendritic cell (DC) vaccines for cancer therapy offer the possibility to let the
patient's own immune system kill cancer cells. However, DC vaccines have shown less …