Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

The use of new sophisticated and highly surface sensitive techniques as synchrotron based
X-ray scattering techniques and in-house infrared reflection absorption spectroscopy …

Soluble aggregates of the microtubule-associated protein tau have been challenging to
assemble and characterize, despite their important role in the development of tauopathies …

The severity of tau pathology in Alzheimer's disease brain correlates closely with disease
progression. Tau immunotherapy has therefore been proposed as a new therapeutic …

The microtubule-associated protein Tau plays a central role in the pathogenesis of
Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of …