[HTML][HTML] Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles

O Escalona-Rayo, P Papadopoulou, B Slütter… - Current Opinion in …, 2024 - Elsevier
Highlights•Lipid nanoparticles are the leading non-viral platform for safe and effective
delivery of RNA-based vaccines and therapeutics.•Upon administration, RNA-lipid …

Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface

P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …

Structure–function relationship of phase-separated liposomes containing diacylglycerol analogues

P Papadopoulou, G Arias-Alpizar, P Weeda… - Biomaterials …, 2024 - pubs.rsc.org
The composition and morphology of lipid-based nanoparticles can influence their overall in
vivo behavior. Previously, we demonstrated that phase separation in liposomes composed …

Deconvolving Passive and Active Targeting of Liposomes Bearing LDL Receptor Binding Peptides Using the Zebrafish Embryo Model

D Bi, A Van Hal, D Aschmann, M Shen, H Zhang, L Su… - Small, 2024 - Wiley Online Library
Improving target versus off‐target ratio in nanomedicine remains a major challenge for
increasing drug bioavailability and reducing toxicity. Active targeting using ligands on …

Lipase-mediated selective hydrolysis of lipid droplets in phase separated-liposomes

P Papadopoulou, R van der Pol, N van Hilten… - 2023 - chemrxiv.org
The membrane-protein interface in lipid nanoparticles (LNPs) is important for their in vivo
behavior. Better understanding may assist to evolve current drug delivery methods to more …

[PDF][PDF] Hal,. an, schmann

D Bi - D., Shen, M., Zhang, H., Su, L …, 2024 - scholarlypublications …
Improving target versus off-target ratio in nanomedicine remains a major challenge for
increasing drug bioavailability and reducing toxicity. Active targeting using ligands on …

[PDF][PDF] DOaG-containing mRNA-LNPs specifically target and transfect brain endothelial cells in zebrafish embryos

P Papadopoulou - scholarlypublications …
Lipid nanoparticle (LNP) technology has unlocked the potential of mRNA therapeutics, and
current developments in the field focus on tissuetargeted therapies for disease-specific …

[PDF][PDF] an.(2024, No ember 19)

WL Os - from https://hdl. handle. net/1887/4139161 … - scholarlypublications …
Ad ancing image-based localization of lipid-based nanomedicines for the exploration of targeted
drug deli er Page 1 Ad ancing image-based localization of lipid-based nanomedicines for the …