Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders
Highlights•MIF plays a key part in inflammatory diseases and cancer.•Many structural
scaffolds are available for MIF inhibition.•Not all studies provide proper assessment of MIF …
scaffolds are available for MIF inhibition.•Not all studies provide proper assessment of MIF …
The Chromenopyridine Scaffold: A Privileged Platform in Drug Design
F Pedroso de Lima, M Costa, A Sousa, MF Proença - Molecules, 2024 - mdpi.com
The chromenopyridine scaffold represents an important class of heterocyclic compounds
exhibiting a broad spectrum of biological properties. This review describes novel and …
exhibiting a broad spectrum of biological properties. This review describes novel and …
Allosteric inhibitors of macrophage migration inhibitory factor (MIF) Interfere with Apoptosis-Inducing factor (AIF) Co-Localization to prevent Parthanatos
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential
signaling protein associated with inflammation and cancers. One of the newly described …
signaling protein associated with inflammation and cancers. One of the newly described …
Potential of multi-strain probiotics extract as an anti-inflammatory agent through inhibition of macrophage migration inhibitory factor activity
D Nyotohadi, T Kok - Functional Foods in Health and Disease, 2023 - ffhdj.com
Background: Probiotics are reported to have a role for improving health conditions and
reduce the risk of diseases associated with inflammation. However, how they affect …
reduce the risk of diseases associated with inflammation. However, how they affect …
[HTML][HTML] Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor (MIF) is a versatile protein that plays a role in
inflammation, autoimmune diseases and cancers. Development of novel inhibitors will …
inflammation, autoimmune diseases and cancers. Development of novel inhibitors will …
Identification and structure–activity relationships of dietary flavonoids as human macrophage migration inhibitory factor (MIF) inhibitors
L Yang, D Guo, C Fan - Journal of Agricultural and Food …, 2021 - ACS Publications
Dietary flavonoids are known to have anti-inflammatory and anticancer effects, but their
influences on human macrophage migration inhibitory factor (MIF), a vital proinflammatory …
influences on human macrophage migration inhibitory factor (MIF), a vital proinflammatory …
Repurposing old drugs as novel inhibitors of human MIF from structural and functional analysis
L Yang, C Yang, L Wang, Z Yang, D Guo… - Bioorganic & Medicinal …, 2022 - Elsevier
Human macrophage migration inhibitory factor (MIF) is an important pro-inflammatory
cytokine that plays multiple pleiotropic functions. It is considered as a promising therapeutic …
cytokine that plays multiple pleiotropic functions. It is considered as a promising therapeutic …
Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming
E Vámos, N Kálmán, EM Sturm, BB Nayak, J Teppan… - Antioxidants, 2023 - mdpi.com
Macrophage polarization is highly involved in autoimmunity. M1 polarized macrophages
drive inflammation and undergo metabolic reprogramming, involving downregulation of …
drive inflammation and undergo metabolic reprogramming, involving downregulation of …
Tandem Sulfonylative Annulation/Halogenation of 1, 7-Enynes with Sodium Sulfinate and TBAX for the Assembly of 4-Methylenechromanes
FP Xia, YM Wu, FZ Hu, XH Zhang… - The Journal of Organic …, 2024 - ACS Publications
An effective and stereoselective synthesis of halogenated (E)-4-methylenechromanes with a
sulfonyl group was developed via the copper-catalyzed sulfonylative annulation …
sulfonyl group was developed via the copper-catalyzed sulfonylative annulation …
Sonochemical synthesis of benzylidene derivatives of enolizable carbonyls and their analogues in aqueous ethanol
PJ Patel, HR Chaudhary, VK Gupta… - Research on Chemical …, 2024 - Springer
This work describes an efficient, concise, and green sonochemical synthesis of benzylidene
derivatives of enolizable carbonyls featuring barbituric acid derivatives, pyrazole-5-one, and …
derivatives of enolizable carbonyls featuring barbituric acid derivatives, pyrazole-5-one, and …