Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy

YC Yang, Q Jiang, KP Yang, L Wang, G Sethi… - Cell Death Discovery, 2024 - nature.com
Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of
intercellular communication in various physiological and pathological processes. These …

Cancer bioenergetics and tumor microenvironments—Enhancing chemotherapeutics and targeting resistant niches through nanosystems

A Farhana, A Alsrhani, YS Khan, Z Rasheed - Cancers, 2023 - mdpi.com
Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …

Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

Immunologic tumor microenvironment modulators for turning cold tumors hot

GR Khosravi, S Mostafavi, S Bastan… - Cancer …, 2024 - Wiley Online Library
Tumors can be classified into distinct immunophenotypes based on the presence and
arrangement of cytotoxic immune cells within the tumor microenvironment (TME). Hot …

Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer

M El-Tanani, H Nsairat, AA Aljabali… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction The resistance to chemotherapy is a significant hurdle in breast cancer
treatment, prompting the exploration of innovative strategies. This review discusses the …

Nanosensors Monitor Intracellular GSH Depletion: GSH Triggers Cu (II) for Tumor Imaging and Inhibition

Y Wang, K Huang, T Wang, L Liu, F Yu, W Sun, W Yao… - Small, 2024 - Wiley Online Library
Glutathione (GSH) is the primary antioxidant in cells, and GSH consumption will break the
redox balance in cells. Based on this, a method that uses high concentrations of GSH in the …

SP1 undergoes phase separation and activates RGS20 expression through super-enhancers to promote lung adenocarcinoma progression

L Shan, W Wang, L Du, D Li, Y Wang, Y Xie… - Proceedings of the …, 2024 - pnas.org
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, but
the underlying molecular mechanisms remain largely unclear. The transcription factor (TF) …

Insights on the role of polyphenols in combating cancer drug resistance

M Farhan - Biomedicines, 2023 - mdpi.com
Chemotherapy resistance is still a serious problem in the treatment of most cancers. Many
cellular and molecular mechanisms contribute to both inherent and acquired drug …

CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers

Q Peng, B Ren, K Xin, W Liu, MS Alam, Y Yang… - European Journal of …, 2023 - Springer
Background The mechanisms whereby CYFIP2 acts in tumor development and drives
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …

A comprehensive pan-cancer analysis of CDH5 in immunological response

Y Li, Q Wu, J Lv, J Gu - Frontiers in Immunology, 2023 - frontiersin.org
Background Cadherin 5 (CDH5) functions critically in maintaining cell adhesion and integrity
of endothelial and vascular cells. The expression of CDH5 is abnormal in tumor cells, which …