Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy
Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of
intercellular communication in various physiological and pathological processes. These …
intercellular communication in various physiological and pathological processes. These …
Cancer bioenergetics and tumor microenvironments—Enhancing chemotherapeutics and targeting resistant niches through nanosystems
Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …
Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
Immunologic tumor microenvironment modulators for turning cold tumors hot
GR Khosravi, S Mostafavi, S Bastan… - Cancer …, 2024 - Wiley Online Library
Tumors can be classified into distinct immunophenotypes based on the presence and
arrangement of cytotoxic immune cells within the tumor microenvironment (TME). Hot …
arrangement of cytotoxic immune cells within the tumor microenvironment (TME). Hot …
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer
Introduction The resistance to chemotherapy is a significant hurdle in breast cancer
treatment, prompting the exploration of innovative strategies. This review discusses the …
treatment, prompting the exploration of innovative strategies. This review discusses the …
Nanosensors Monitor Intracellular GSH Depletion: GSH Triggers Cu (II) for Tumor Imaging and Inhibition
Y Wang, K Huang, T Wang, L Liu, F Yu, W Sun, W Yao… - Small, 2024 - Wiley Online Library
Glutathione (GSH) is the primary antioxidant in cells, and GSH consumption will break the
redox balance in cells. Based on this, a method that uses high concentrations of GSH in the …
redox balance in cells. Based on this, a method that uses high concentrations of GSH in the …
SP1 undergoes phase separation and activates RGS20 expression through super-enhancers to promote lung adenocarcinoma progression
L Shan, W Wang, L Du, D Li, Y Wang, Y Xie… - Proceedings of the …, 2024 - pnas.org
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, but
the underlying molecular mechanisms remain largely unclear. The transcription factor (TF) …
the underlying molecular mechanisms remain largely unclear. The transcription factor (TF) …
Insights on the role of polyphenols in combating cancer drug resistance
M Farhan - Biomedicines, 2023 - mdpi.com
Chemotherapy resistance is still a serious problem in the treatment of most cancers. Many
cellular and molecular mechanisms contribute to both inherent and acquired drug …
cellular and molecular mechanisms contribute to both inherent and acquired drug …
CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers
Q Peng, B Ren, K Xin, W Liu, MS Alam, Y Yang… - European Journal of …, 2023 - Springer
Background The mechanisms whereby CYFIP2 acts in tumor development and drives
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …
immune infiltration have been poorly explored. Thus, this study aimed to identifying the role …
A comprehensive pan-cancer analysis of CDH5 in immunological response
Y Li, Q Wu, J Lv, J Gu - Frontiers in Immunology, 2023 - frontiersin.org
Background Cadherin 5 (CDH5) functions critically in maintaining cell adhesion and integrity
of endothelial and vascular cells. The expression of CDH5 is abnormal in tumor cells, which …
of endothelial and vascular cells. The expression of CDH5 is abnormal in tumor cells, which …