The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

Systemic therapy of breast cancer can include chemotherapy, hormonal therapy and
targeted therapy. Prognostic biomarkers are able to predict survival and predictive …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …

Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …

Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging
of tumors. In this study, we show the preferential uptake and retention of two hepatamethine …

Organic anion transporting polypeptides (OATPs) are members of the SLCO gene
superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies …

Abstract IR-780 iodide, a near-infrared fluorescent heptamethine dye, has been recently
characterized to exhibit preferential accumulation property in the mitochondria of tumor cells …

The phytochemical resveratrol has been shown to exert numerous health benefits in
preclinical studies, but its rapid metabolism and resulting poor bioavailability may limit …

Oxaliplatin chemoresistance is a major challenge in the clinical treatment of colorectal
cancer (CRC), which is one of the most common malignancies worldwide. In this study, we …

Liver disease can alter the disposition of xenobiotics and endogenous substances.
Regulatory agencies such as the Food and Drug Administration and the European …