Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

Abstract The evolutionarily conserved Par3/Par6/aPKC complex regulates the polarity
establishment of diverse cell types and distinct polarity-driven functions. However, how the …

Planar cell polarity (PCP) is cellular polarity within the plane of an epithelial tissue or organ.
PCP is established through interactions of the core Frizzled (Fz)/PCP factors and, although …

The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells
within the plane of a tissue but it also plays a role in a range of cell migration events during …

Locus heterogeneity characterizes a variety of skeletal dysplasias often due to interacting or
overlapping signaling pathways. Robinow syndrome is a skeletal disorder historically …

Planar cell polarity (PCP) signaling controls tissue morphogenesis by coordinating collective
cell behaviors. We show a critical role for the core PCP proteins Celsr1 and Vangl2 in the …

Epithelia containing multiciliated cells align beating cilia along a common planar axis
specified by the conserved planar cell polarity (PCP) pathway. Specification of the planar …

The growth and dynamics of multicellular tissues involve tightly regulated and coordinated
morphogenetic cell behaviors, such as shape changes, movement, and division, which are …

Drosophila has been the key model system for studies on planar cell polarity (PCP). The rich
morphology of the insect exoskeleton contains many structures that display PCP. Among …