The bovine herpesvirus 1 latency-reactivation cycle, a chronic problem in the cattle industry

JB Ostler, C Jones - Viruses, 2023 - mdpi.com
Bovine alphaherpesvirus 1 (BoHV-1) is a persistent and recurring disease that affects cattle
worldwide. It is a major contributor to bovine respiratory disease and reproductive failure in …

Bovine herpesvirus 1 counteracts immune responses and immune-surveillance to enhance pathogenesis and virus transmission

C Jones - Frontiers in Immunology, 2019 - frontiersin.org
Infection of cattle by bovine herpesvirus 1 (BoHV-1) can culminate in upper respiratory tract
disorders, conjunctivitis, or genital disorders. Infection also consistently leads to transient …

A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61

DP Depledge, WJD Ouwendijk, T Sadaoka… - Nature …, 2018 - nature.com
Abstract Varicella-zoster virus (VZV), an alphaherpesvirus, establishes lifelong latent
infection in the neurons of> 90% humans worldwide, reactivating in one-third to cause …

Molecular aspects of varicella-zoster virus latency

DP Depledge, T Sadaoka, WJD Ouwendijk - Viruses, 2018 - mdpi.com
Primary varicella-zoster virus (VZV) infection causes varicella (chickenpox) and the
establishment of a lifelong latent infection in ganglionic neurons. VZV reactivates in about …

Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate …

FS El-Mayet, C Jones - Journal of Virology, 2024 - Am Soc Microbiol
ABSTRACT Bovine alphaherpesvirus 1 (BoHV-1) infections cause respiratory tract disorders
and suppress immune responses, which can culminate in bacterial pneumonia. Following …

Stress triggers expression of bovine herpesvirus 1 infected cell protein 4 (bICP4) RNA during early stages of reactivation from latency in pharyngeal tonsil

G Toomer, A Workman, KS Harrison, E Stayton… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Bovine herpesvirus 1 (BoHV-1), an important pathogen of cattle, establishes
lifelong latency in sensory neurons within trigeminal ganglia (TG) after acute infection. The …

Cellular transcription factors induced in trigeminal ganglia during dexamethasone-induced reactivation from latency stimulate bovine herpesvirus 1 productive …

A Workman, J Eudy, L Smith, L Frizzo da Silva… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT Bovine herpesvirus 1 (BHV-1), an alphaherpesvirinae subfamily member,
establishes latency in sensory neurons. Elevated corticosteroid levels, due to stress …

Regulation of the latency–reactivation cycle by products encoded by the bovine herpesvirus 1 (BHV-1) latency-related gene

C Jones, LF da Silva, D Sinani - Journal of neurovirology, 2011 - Springer
Like other α-herpesvirinae subfamily members, the primary site for bovine herpesvirus 1
(BHV-1) latency is ganglionic sensory neurons. Periodically BHV-1 reactivates from latency …

A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation

X Jiang, D Brown, N Osorio, C Hsiang, L Li… - Journal of …, 2015 - Springer
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) encodes
several microRNAs. One of these, miR-H2, overlaps and is antisense to the ICP0 gene and …

Bovine herpes virus 1 (BHV-1) and herpes simplex virus type 1 (HSV-1) promote survival of latently infected sensory neurons, in part by inhibiting apoptosis

C Jones - Journal of Cell Death, 2013 - journals.sagepub.com
α-Herpesvirinae subfamily members, including herpes simplex virus type 1 (HSV-1) and
bovine herpes virus 1 (BHV-1), initiate infection in mucosal surfaces. BHV-1 and HSV-1 …