The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Biomarkers are indispensable to the development of new tuberculosis therapeutics and
vaccines. The most robust biomarkers measure factors that are essential to the underlying …

Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …

Several genes coding for different cytokines may affect host susceptibility to tuberculosis.
This study investigates the relationship of the single base change polymorphic variants …

Active tuberculosis (TB) is associated with prolonged suppression of Mycobacterium
tuberculosis (MTB)-specific immune responses, but mechanisms involved are understood …

TNF-α has long been regarded as a proimmune cytokine involved in antimicrobial type 1
immunity. However, the precise role of TNF-α in antimicrobial type 1 immunity remains …

Unlike other opportunistic infections associated with human immunodeficiency virus (HIV)
type 1, tuberculosis (TB) occurs throughout the course of HIV-1 infection, and, as a chronic …

A hallmark of M. tuberculosis infection is the ability of most (90–95%) healthy adults to
control infection through acquired immunity, in which antigen specific T cells and …

The diagnosis of pleural tuberculosis (plTB) by the analysis of pleural effusions (PEs) with
standard diagnostic tools is difficult. In routine clinical practice, the present authors …

The granuloma plays a critical role in the host immune response to Mycobacterium
tuberculosis, containing the organism and confining it in a latent state in most infected …