Long noncoding RNAs in cancer: mechanisms of action and technological advancements
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …
being defined as a category of genetic elements, leaving its mark on the field of cancer …
Critical roles of non-histone protein lysine methylation in human tumorigenesis
R Hamamoto, V Saloura, Y Nakamura - Nature Reviews Cancer, 2015 - nature.com
Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …
critical roles in histone modification. A large body of evidence has indicated that their …
[HTML][HTML] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster
within regions enriched for genes encoding developmentally important transcription factors …
within regions enriched for genes encoding developmentally important transcription factors …
[HTML][HTML] Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers
Summary Trimethyl-lysine (me3) modifications on histones are the most stable epigenetic
marks and they control chromatin-mediated regulation of gene expression. Here, we …
marks and they control chromatin-mediated regulation of gene expression. Here, we …
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
AP Bracken, N Dietrich, D Pasini… - Genes & …, 2006 - genesdev.cshlp.org
The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …
for embryonic development and stem cell renewal and are commonly deregulated in cancer …
Polycomb silencing mechanisms and the management of genomic programmes
YB Schwartz, V Pirrotta - Nature Reviews Genetics, 2007 - nature.com
Polycomb group complexes, which are known to regulate homeotic genes, have now been
found to control hundreds of other genes in mammals and insects. First believed to …
found to control hundreds of other genes in mammals and insects. First believed to …
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
The chromodomain (CD) of the Drosophila Polycomb protein exhibits preferential binding
affinity for histone H3 when trimethylated at lysine 27. Here we have investigated the five …
affinity for histone H3 when trimethylated at lysine 27. Here we have investigated the five …
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
S Schoeftner, AK Sengupta, S Kubicek… - The EMBO …, 2006 - embopress.org
In mammals X inactivation is initiated by expression of Xist RNA and involves the recruitment
of Polycomb repressive complex 1 (PRC1) and 2 (PRC2), which mediate chromosome‐wide …
of Polycomb repressive complex 1 (PRC1) and 2 (PRC2), which mediate chromosome‐wide …
Polycomb/Trithorax response elements and epigenetic memory of cell identity
L Ringrose, R Paro - 2007 - journals.biologists.com
Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal
pieces. Just a few hundred base pairs long, these elements can remember and maintain the …
pieces. Just a few hundred base pairs long, these elements can remember and maintain the …
Silencing by plant Polycomb‐group genes requires dispersed trimethylation of histone H3 at lysine 27
D Schubert, L Primavesi, A Bishopp, G Roberts… - The EMBO …, 2006 - embopress.org
The plant Polycomb‐group (Pc‐G) protein CURLY LEAF (CLF) is required to repress targets
such as AGAMOUS (AG) and SHOOTMERISTEMLESS (STM). Using chromatin …
such as AGAMOUS (AG) and SHOOTMERISTEMLESS (STM). Using chromatin …