[HTML][HTML] Proliferation and apoptosis pathways and factors in oral squamous cell carcinoma

S He, R Chakraborty, S Ranganathan - International journal of molecular …, 2022 - mdpi.com
Oral cancer is the most common form of head and neck squamous cell carcinoma (HNSCC)
and most frequently presents as oral squamous cell carcinoma (OSCC), which is associated …

Ras oncogenes in oral cancer: the past 20 years

AK Murugan, AK Munirajan, N Tsuchida - Oral oncology, 2012 - Elsevier
Oral squamous cell carcinoma (OSCC) of head and neck is associated with high morbidity
and mortality in both Western and Asian countries. Several risk factors for the development …

[HTML][HTML] Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical …

A Paniccia, PM Polanco, BA Boone, AI Wald… - Gastroenterology, 2023 - Elsevier
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …

[HTML][HTML] Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma

Y Cai, S Dodhia, GH Su - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The phosphoinositide 3-kinase (PI3K) signaling pathway is the most commonly
mutated pathway in head and neck squamous cell carcinoma (HNSCC). There are several …

An update of knowledge on PD‐L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives

D Lenouvel, MÁ González‐Moles, A Talbaoui… - Oral …, 2020 - Wiley Online Library
Programmed cell death‐ligand 1 (PD‐L1) is a transmembrane protein that acts as a co‐
inhibitory factor in the immune response. Its receptor, programmed cell death protein 1 (PD …

[HTML][HTML] Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

N Batta, M Pandey - World Journal of Surgical Oncology, 2019 - Springer
Oral squamous cell cancer (OSCC) is a common malignancy attributed to use of chewing
smokeless tobacco and smoking. Most of the targeted strategies are based on EGFR …

Genetic deregulation of the PIK3CA oncogene in oral cancer

AK Murugan, AK Munirajan, N Tsuchida - Cancer letters, 2013 - Elsevier
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is one of the most
commonly deregulated pathways in human cancers. PI3K comprises a catalytic (p110α) and …

Overcoming cetuximab resistance in HNSCC: the role of AURKB and DUSP proteins

C Boeckx, KO de Beeck, A Wouters… - Cancer letters, 2014 - Elsevier
Unraveling the underlying mechanisms of cetuximab resistance in head and neck
squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non …

Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma

Y Cohen, N Goldenberg-Cohen, B Shalmon, T Shani… - Oral oncology, 2011 - Elsevier
The phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma (AKT) viral oncogene pathway
is involved in regulating the signaling of multiple biological processes such as apoptosis …

[HTML][HTML] Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review

A Starzyńska, A Sejda, P Adamska… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Abstract Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are
reported annually worldwide. Despite development in OSCC management, the outcome is …