Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …

Tubulin posttranslational modifications are currently emerging as important regulators of the
microtubule cytoskeleton and thus have a strong potential to be implicated in a number of …

Purpose Current sequencing strategies can genetically solve 55–60% of inherited retinal
degeneration (IRD) cases, despite recent progress in sequencing. This can partially be …

Past 25y have witnessed an exponential increase in knowledge and understanding of
ocular diseases and their respective genetic underpinnings. As a result, scientists have …

CRISPR-based targeted genome editing is bringing revolutionary changes in the research
arena of biological sciences. CRISPR/Cas9 has been explored as an efficient therapeutic …

Patients with inherited retinal dystrophies (IRDs) were recruited from two understudied
populations: Mexico and Pakistan as well as a third well-studied population of European …

Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

Twin studies and family studies suggest an important genetic basis for keratoconus (KC).
Involvement and association of several genes with the disease has been reported …