Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

The inherent stochasticity in the gene product levels can drive single cells within an
isoclonal population to different phenotypic states. The dynamic nature of this intercellular …

In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …

In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …

In isogenic cell populations, cells can switch back and forth between different gene
expression states. These expression states can be biologically relevant. For example, a …

In isogenic cell populations, cells can switch between different gene expression states.
These expression states can be biologically relevant. For example, a certain expression …

Sometimes cells within the same population exhibit di↵ erent characteristics, even when
they have the same DNA. This non-genetic heterogeneity is not only interesting as a …