Computational approaches to modelling and optimizing cancer treatment
TO McDonald, YC Cheng, C Graser, PB Nicol… - Nature Reviews …, 2023 - nature.com
Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …
responses in cancer therapy. In this Review, we provide an overview of such computational …
Probing transient memory of cellular states using single-cell lineages
A Singh, M Saint-Antoine - Frontiers in microbiology, 2023 - frontiersin.org
The inherent stochasticity in the gene product levels can drive single cells within an
isoclonal population to different phenotypic states. The dynamic nature of this intercellular …
isoclonal population to different phenotypic states. The dynamic nature of this intercellular …
A fluctuation-based approach to infer kinetics and topology of cell-state switching
In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …
fluctuations in copy numbers over time. As a consequence, single cells within the same …
Fluctuation-based approaches to infer kinetics of cell-state switching
M Saint-Antoine, R Grima… - 2022 IEEE 61st …, 2022 - ieeexplore.ieee.org
In the noisy cellular environment, RNAs and proteins are subject to considerable stochastic
fluctuations in copy numbers over time. As a consequence, single cells within the same …
fluctuations in copy numbers over time. As a consequence, single cells within the same …
Moment-based estimation of state-switching rates in cell populations
M Saint-Antoine, A Singh - bioRxiv, 2022 - biorxiv.org
In isogenic cell populations, cells can switch back and forth between different gene
expression states. These expression states can be biologically relevant. For example, a …
expression states. These expression states can be biologically relevant. For example, a …
Estimating rates of switching between cell states using a single time point measurement
MM Saint-Antoine, A Singh - IFAC-PapersOnLine, 2022 - Elsevier
In isogenic cell populations, cells can switch between different gene expression states.
These expression states can be biologically relevant. For example, a certain expression …
These expression states can be biologically relevant. For example, a certain expression …
[图书][B] Computational Tools for Modeling Heterogeneity Within Cell Populations
M Saint-Antoine - 2023 - search.proquest.com
Sometimes cells within the same population exhibit di↵ erent characteristics, even when
they have the same DNA. This non-genetic heterogeneity is not only interesting as a …
they have the same DNA. This non-genetic heterogeneity is not only interesting as a …