Highlights•Salmonella enterica resides within the cytosol or a membrane-bound vacuole in
epithelial cells.•Intestinal and gall bladder epithelial cells are sites of cytosolic colonization …

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-
dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since …

Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative
diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of …

SUMMARY A wide spectrum of pathogenic bacteria and protozoa has adapted to an
intracellular life-style, which presents several advantages, including accessibility to host cell …

Modulation of protein function is used to intervene in cellular processes but is often done
indirectly by means of introducing DNA or mRNA encoding the effector protein. Thus far …

Survival within macrophages is a central feature of Mycobacterium tuberculosis
pathogenesis. Despite significant advances in identifying new immunological parameters …

Numerous pathological amyloid proteins spread from cell to cell during neurodegenerative
disease, facilitating the propagation of cellular pathology and disease progression …

Pathogenic and commensal Gram‐negative bacteria produce and release outer membrane
vesicles (OMV s), which present several surface antigens and play an important role for …

Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce
innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium …

Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …