Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease

L Amirifar, A Shamloo, R Nasiri, NR de Barros… - Biomaterials, 2022 - Elsevier
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications

LA Milton, MS Viglione, LJY Ong, GP Nordin, YC Toh - Lab on a Chip, 2023 - pubs.rsc.org
Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …

Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

Advances in microfluidic in vitro systems for neurological disease modeling

PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

[HTML][HTML] Brain-on-a-chip: A history of development and future perspective

S Bang, S Jeong, N Choi, HN Kim - Biomicrofluidics, 2019 - pubs.aip.org
Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …

Biomedical applications of electrical stimulation

S Zhao, AS Mehta, M Zhao - Cellular and molecular life sciences, 2020 - Springer
This review provides a comprehensive overview on the biomedical applications of electrical
stimulation (EStim). EStim has a wide range of direct effects on both biomolecules and cells …

A review of functional electrical stimulation treatment in spinal cord injury

S Luo, H Xu, Y Zuo, X Liu, AH All - Neuromolecular medicine, 2020 - Springer
Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction
in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include …

[HTML][HTML] Engineered neural circuits for modeling brain physiology and neuropathology

S Bang, KS Hwang, S Jeong, IJ Cho, N Choi, J Kim… - Acta Biomaterialia, 2021 - Elsevier
The neural circuits of the central nervous system are the regulatory pathways for feeling,
motion control, learning, and memory, and their dysfunction is closely related to various …

[HTML][HTML] Brain physiome: A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

Y Seo, S Bang, J Son, D Kim, Y Jeong, P Kim, J Yang… - Bioactive Materials, 2022 - Elsevier
In the last few decades, adverse reactions to pharmaceuticals have been evaluated using
2D in vitro models and animal models. However, with increasing computational power, and …

Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application

Z Wang, Y Zhang, Z Li, H Wang, N Li, Y Deng - Small, 2023 - Wiley Online Library
As an ideal in vitro model, brain‐on‐chip (BoC) is an important tool to comprehensively
elucidate brain characteristics. However, the in vitro model for the definition scope of BoC …