Abstract Background and Aim Treatment with antituberculosis (TB) drugs produces liver
damage in a large proportion of patients. Isoniazid, an antibacterial drug, is primarily …

We describe 11 cases of anti-tuberculosis DRESS (drug-related rash with eosinophilia and
systemic symptoms) syndrome, a potentially serious complication of treatment that led to …

Background: Considering the genetic characteristics of people with anti-tuberculosis (TB)-
drug-induced liver injury (ATDILI), genetic factors and their consequences for treatment …

Background Several pathogenesis and genetic factors influence predisposition to
antituberculosis drug-induced hepatotoxicity (ATDH) especially for isoniazid (INH) …

Abstract Arylamine N-acetyltransferase 2 (NAT2) metabolizes isoniazid (INH) and Single
Nucleotide Polymorphisms (SNP) responsible for its activity has been reported. The aim of …

Background: Genetic variants in NAT2 are associated with pharmacokinetic variation of
isoniazid, the cornerstone of antituberculosis treatment. We investigated the acetylator …

Abstract Background N‐acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II
metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of …

Methods We examined 331 TB patients who had been treated with anti-TB drugs. TagSNP
of NAT2 genotyping was determined using PCR-restriction fragment length polymorphisms …

Psoriasis is a common, chronic, and autoimmune skin disease. Factors that play a role in
etiopathogenesis of psoriasis include internal factors such as genetic susceptibility and …

Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine
children under isoniazid treatment. - Abstract - Europe PMC Sign in | Create an account …