[HTML][HTML] Paxlovid (Nirmatrelvir/Ritonavir): A new approach to Covid-19 therapy?
Despite the need for novel, effective therapeutics for the COVID-19 pandemic, no curative
regimen is yet available, therefore patients are forced to rely on supportive and nonspecific …
regimen is yet available, therefore patients are forced to rely on supportive and nonspecific …
Targeting the dimerization of the main protease of coronaviruses: a potential broad-spectrum therapeutic strategy
A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir
The COVID-19 pandemic continues to be a public health threat. Multiple mutations in the
spike protein of emerging variants of SARS-CoV-2 appear to impact on the effectiveness of …
spike protein of emerging variants of SARS-CoV-2 appear to impact on the effectiveness of …
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
S Günther, PYA Reinke, Y Fernández-García, J Lieske… - Science, 2021 - science.org
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous
human suffering. To date, no effective drug is available to directly treat the disease. In a …
human suffering. To date, no effective drug is available to directly treat the disease. In a …
[HTML][HTML] Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
The main protease, Mpro (or 3CLpro) in SARS-CoV-2 is a viable drug target because of its
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal …
[HTML][HTML] A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
S Hattori, N Higashi-Kuwata, H Hayashi, SR Allu… - Nature …, 2021 - nature.com
Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available.
Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h …
Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h …
In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is distinctly infective and
there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as …
there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as …
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
T Muramatsu, C Takemoto, YT Kim… - Proceedings of the …, 2016 - National Acad Sciences
The 3C-like protease (3CLpro) of severe acute respiratory syndrome coronavirus (SARS-
CoV) cleaves 11 sites in the polyproteins, including its own N-and C-terminal …
CoV) cleaves 11 sites in the polyproteins, including its own N-and C-terminal …
Identification of potential binders of the main protease 3CLpro of the COVID-19 via structure-based ligand design and molecular modeling
M Macchiagodena, M Pagliai, P Procacci - Chemical Physics Letters, 2020 - Elsevier
We have applied a computational strategy, using a combination of virtual screening, docking
and molecular dynamics techniques, aimed at identifying possible lead compounds for the …
and molecular dynamics techniques, aimed at identifying possible lead compounds for the …
[HTML][HTML] Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19
MK Roe, NA Junod, AR Young… - Journal of General …, 2021 - microbiologyresearch.org
Coronavirus protease nsp5 (M pro, 3CL pro) remains a primary target for coronavirus
therapeutics due to its indispensable and conserved role in the proteolytic processing of the …
therapeutics due to its indispensable and conserved role in the proteolytic processing of the …