The medical community recognizes sex-related differences in pathophysiology and
cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre …

Sex differences in cardiovascular disease (CVD) are often recognized from experimental
and clinical studies examining the prevalence, manifestations, and response to therapies …

Inflammation plays a critical role in the development of diabetic cardiomyopathy (DCM),
which has been identified as a major predisposing factor for heart failure in diabetic patients …

Catecholamines play a key role in the regulation of cardiovascular function, classically
through ß 1/2-adrenoreceptors (AR) activation. After ß 3-AR cloning in the late 1980s …

Rationale: βARs (β-adrenergic receptors) are prototypical GPCRs (G protein–coupled
receptors) that play a pivotal role in sympathetic regulation. In heart cells, β1AR signaling …

G protein coupled receptor 55 (GPR55) is expressed throughout the body, and although its
exact physiological function is unknown, studies have suggested a role in the cardiovascular …

Impaired cardiac β-adrenoceptor signaling is an important cause of sepsis-induced
myocardial depression in man and experimental animals. We examined the effect of …

This study sought to determine if metoprolol succinate ER (MET), and nebivolol (NEB), a β1-
AR with increased bioavailability of nitric oxide (NO), would have differing effects on plasma …

Currently, we have little information concerning the involvement of β3-adrenergic receptors
(AR) in cardiovascular regulation in fishes. The goal of this study was to investigate the effect …

Cardiovascular disease (CVD) is a public health concern, and the third cause of death
worldwide. Several epidemiological studies and experimental approaches have …