Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion
of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in …

The graft‐versus‐leukaemia (GVL) effect is a central component of the stem cell allograft's
ability to cure haematological malignancies. The GVL effect is mediated by donor‐derived …

Regulatory T cells (Tregs) are an essential component of the cellular immune response,
occupying a key role in maintaining immunological tolerance and present an attractive …

Blocking the migration of regulatory T cells (Tregs) to the tumor microenvironment is a
promising strategy for tumor immunotherapy. Treg accumulation in the leukemic …

Regulatory T (Treg) cells contribute to immune evasion by malignancies. To investigate their
importance in non-Hodgkin lymphoma (NHL), we enumerated Treg cells in peripheral blood …

Adult bone marrow (BM) hematopoietic stem cells (HSCs) are maintained in a quiescent
state and sustain the continuous production of all types of blood cells. HSCs reside in a …

The relationships between immunological dysfunction, loss of tolerance and hematologic
malignancies have been a focus of attention in attempts to understand the appearance of a …

3 Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S et al. Prevalence and
clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. Br J …

Regulatory T cells (Tregs) have a fundamental function in monitoring the immune
homeostasis in healthy individuals. In cancer and, in particular, in hematological …

The infusion of donor regulatory T cells (Tregs) has been used to prevent acute graft-versus-
host disease (GVHD) in mice and has shown promise in phase 1 clinical trials. Previous …