Emerging new therapeutic antibody derivatives for cancer treatment

S Jin, Y Sun, X Liang, X Gu, J Ning, Y Xu… - Signal transduction and …, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …

A guide to: generation and design of nanobodies

S Muyldermans - The FEBS journal, 2021 - Wiley Online Library
A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

CCS Chini, TR Peclat, GM Warner, S Kashyap… - Nature …, 2020 - nature.com
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …

Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers

A Aghebati‐Maleki, S Dolati, M Ahmadi… - Journal of cellular …, 2020 - Wiley Online Library
Rapid growth in nanotechnology toward the development of nanomedicine agents holds
massive promise to improve therapeutic approaches against cancer. Nanomedicine …

The era of digital health: A review of portable and wearable affinity biosensors

J Tu, RM Torrente‐Rodríguez… - Advanced Functional …, 2020 - Wiley Online Library
Digital health facilitated by wearable/portable electronics and big data analytics holds great
potential in empowering patients with real‐time diagnostics tools and information. The …

Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics

P Bannas, J Hambach, F Koch-Nolte - Frontiers in immunology, 2017 - frontiersin.org
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …

[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy

BH Kok, HT Lim, CP Lim, NS Lai, CY Leow, CH Leow - Virus research, 2023 - Elsevier
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Nanobodies: natural single-domain antibodies

S Muyldermans - Annual review of biochemistry, 2013 - annualreviews.org
Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …

[HTML][HTML] Cell membrane-coated nanomaterials for cancer therapy

S Zeng, Q Tang, M Xiao, X Tong, T Yang, D Yin, L Lei… - Materials Today Bio, 2023 - Elsevier
With the development of nanotechnology, nanoparticles have emerged as a delivery carrier
for tumor drug therapy, which can improve the therapeutic effect by increasing the stability …

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

DA Richards, A Maruani, V Chudasama - Chemical science, 2017 - pubs.rsc.org
Recent advances in nanomedicine have shown that dramatic improvements in nanoparticle
therapeutics and diagnostics can be achieved through the use of disease specific targeting …