The bone marrow (BM) niche is the spatial structure within the intra-trabecular spaces of
spongious bones and of the cavity of long bones where adult haematopoietic stem cells …

骨缺损达到一定范围及距离后, 机体自身无法自行修复, 即临界骨缺损, 需自体骨移植,
异体骨移植或骨组织工程进行修复. 骨缺损动物模型常被用以评估骨组织工程中骨替代生物材料 …

Sepsis is a dysregulated systemic immune response to infection ie responsible for∼ 35% of
in-hospital deaths at a significant fiscal healthcare cost. Our laboratory, among others, has …

Adult T cell leukaemia (ATL), caused by infection with human T‐lymphotropic virus type 1
(HTLV‐1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we …

Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia, a disease
commonly associated with hypercalcemia and osteolysis. There is no effective treatment for …

Rodent models have contributed significantly to the understanding of haematological
malignancies. One important model system in this context are patient-derived xenografts …

Simple Summary Adult T-cell leukemia (ATL) Leukemia is an aggressive, peripheral blood
(T-cell) neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1) infection …

Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1α
(MIP-1α) are important factors that increase bone resorption and hypercalcemia in adult T …

Athymic or nude (nu/nu) mice Mice lack T lymphocytes CAH Cancer-associated
hypercalcemia HHM Humoral hypercalcemia of malignancy NOD mice Nonobese diabetic …