Who is who in adenosine transport

M Pastor-Anglada, S Pérez-Torras - Frontiers in pharmacology, 2018 - frontiersin.org
Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

M Pastor-Anglada, S Pérez-Torras - Frontiers in pharmacology, 2015 - frontiersin.org
Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

Gemcitabine-based chemotherapy in adrenocortical carcinoma: a multicenter study of efficacy and predictive factors

JEK Henning, T Deutschbein, B Altieri… - The Journal of …, 2017 - academic.oup.com
Context Adrenocortical carcinoma (ACC) is rare and confers an unfavorable prognosis in
advanced stages. Other than combination chemotherapy with cisplatin, etoposide …

Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway

T Namba, R Kodama, S Moritomo, T Hoshino… - Cell death & …, 2015 - nature.com
Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid
acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic …

The A2B Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human …

C Giacomelli, S Daniele, C Romei, L Tavanti… - Frontiers in …, 2018 - frontiersin.org
The epithelial-mesenchymal transition (EMT) is a complex process in which cell phenotype
switches from the epithelial to mesenchymal one. The deregulations of this process have …

Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in …

S Warraich, DBJ Bone, D Quinonez, H Ii… - Journal of Bone and …, 2013 - academic.oup.com
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy,
characterized by ectopic calcification of spinal tissues. Symptoms include spine pain and …

Adenosine contribution to normal renal physiology and chronic kidney disease

C Oyarzún, W Garrido, S Alarcón, A Yáñez… - Molecular aspects of …, 2017 - Elsevier
Adenosine is a nucleoside that is particularly interesting to many scientific and clinical
communities as it has important physiological and pathophysiological roles in the kidney …

Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT)

AS Martínez-Ramírez, M Díaz-Muñoz… - Purinergic …, 2017 - Springer
The epithelium-mesenchymal transition (EMT) is an important process of cell plasticity,
consisting in the loss of epithelial identity and the gain of mesenchymal characteristics …

[HTML][HTML] Adenosine A2B receptor-mediated VEGF induction promotes diabetic glomerulopathy

A Cárdenas, C Toledo, C Oyarzún, A Sepúlveda… - Laboratory …, 2013 - Elsevier
Diabetic nephropathy ranks as the most devastating kidney disease worldwide. It
characterizes in the early onset by glomerular hypertrophy, hyperfiltration and mesangial …

Reduced adenosine uptake and its contribution to signaling that mediates profibrotic activation in renal tubular epithelial cells: implication in diabetic nephropathy

C Kretschmar, C Oyarzún, C Villablanca, C Jaramillo… - PLoS …, 2016 - journals.plos.org
Altered nucleoside levels may be linked to pathogenic signaling through adenosine
receptors. We hypothesized that adenosine dysregulation contributes to fibrosis in diabetic …