Congenital heart disease (CHD) is a frequent occurrence, with a prevalence rate of almost
1% in the general population. However, the pathophysiology of the anomalous heart …

Congenital heart defects (CHDs) refer to abnormalities in the heart function that arise at the
fetal stages. It is the most common birth defect that affects 0.8% of all liveborn infants. There …

Congenital heart disease (CHD) is a common structural birth defect worldwide, and defects
typically occur in the walls and valves of the heart or enlarged blood vessels. Chromosomal …

Objectives To evaluate the prevalence, subtypes and postnatal outcomes of congenital heart
defects (CHD) in a cohort of monochorionic diamniotic (MCDA) twin pregnancies …

The objective of this study was to understand and measure epigenetic changes associated
with the occurrence of CHDs by utilizing the discordant monozygotic twin model. A unique …

Background Duplication of the distal end of chromosome 15q has been previously
implicated in a characteristic overgrowth syndrome. Additionally, many patients have other …

Suppressor of cytokine signaling 3 (SOCS3) plays a significant role in the process of
myocardial adaptation to chronic hypoxia. SOCS3 finely regulates cell signaling cross-talk …

Introduction Van der Woude Syndrome (VWS) is an autosomal dominant disorder
responsible for 2% of all syndromic orofacial clefts (OFCs) with IRF6 being the primary …

Objective To evaluate the impact of maternal exposure to polycyclic aromatic hydrocarbons
(PAHs) and methylation levels of CHDs‐candidate genes on the risk of congenital heart …

This Introduction provides both a short reflection on the scientific career of Adriana
Gittenberger-de Groot and an overview of the papers that form the basis of this Special Issue …