Chemically modified or genetically engineered haemoglobins (Hbs) developed as oxygen
therapeutics (often termed'blood substitutes') are designed to correct oxygen deficit due to …

The complications associated with acquiring and storing whole blood for transfusions have
launched substantial efforts to develop a blood substitute. The history of these efforts …

Context Hemoglobin-based blood substitutes (HBBSs) are infusible oxygen-carrying liquids
that have long shelf lives, have no need for refrigeration or cross-matching, and are ideal for …

SEMISYNTHETIC or synthetic preparations of hemoglobin, now termed hemoglobin-based
oxygen carriers (HBOCs), have been in development as an alternative to erythrocytes for …

Two distinct approaches are being explored in red blood cell substitute (RCS) development:
hemoglobin‐based oxygen carriers (HBOCs) and perfluorocarbon‐based oxygen carriers …

Background: The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely
reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery …

Donor blood is a limited resource and its transfusion is associated with significant adverse
effects. Therefore, alternatives have been searched, the ultimate being artificial oxygen (O2) …

Background Data analyzing the short-term outcomes and predictors of blood transfusions
(BTs) in colorectal cancer (CRC) surgery are limited. Methods The American College of …

Background: Producing an alternative to human erythrocytes has been one the most exciting
dreams of medicine. Hemoglobin-based oxygen carriers (HBOCs) derived from purified …

Anemia commonly affects critically ill patients. The causes are multifactorial and include
acute blood loss, blood loss from diagnostic testing and blunted red blood cell production …