Regulation of stress response on the hypothalamic-pituitary-gonadal axis via gonadotropin-inhibitory hormone
YL Son, T Ubuka, K Tsutsui - Frontiers in Neuroendocrinology, 2022 - Elsevier
Under stressful condition, reproductive function is impaired due to the activation of various
components of the hypothalamic–pituitaryadrenal (HPA) axis, which can suppress the …
components of the hypothalamic–pituitaryadrenal (HPA) axis, which can suppress the …
Gonadotropin-inhibitory hormone (GnIH): A new key neurohormone controlling reproductive physiology and behavior
K Tsutsui, T Ubuka - Frontiers in Neuroendocrinology, 2021 - Elsevier
The discovery of novel neurohormones is important for the advancement of
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …
Central and peripheral neuropeptide RFRP-3: a bridge linking reproduction, nutrition, and stress response
This article is an amalgamation of the current status of RFRP-3 (GnIH) in reproduction and
its association with the nutrition and stress-mediated changes in the reproductive activities …
its association with the nutrition and stress-mediated changes in the reproductive activities …
RFRP-3 influences apoptosis and steroidogenesis of yak cumulus cells and compromises oocyte meiotic maturation and subsequent developmental competence
X Xiong, Y Hu, B Pan, Y Zhu, X Fei, Q Yang… - International Journal of …, 2023 - mdpi.com
RF amide-related peptide 3 (RFRP-3), a mammalian ortholog of gonadotropin-inhibitory
hormone (GnIH), is identified to be a novel inhibitory endogenous neurohormonal peptide …
hormone (GnIH), is identified to be a novel inhibitory endogenous neurohormonal peptide …
[HTML][HTML] Discovery of gonadotropin-inhibitory hormone (GnIH), progress in GnIH research on reproductive physiology and behavior and perspective of GnIH research …
K Tsutsui, T Ubuka - Molecular and Cellular Endocrinology, 2020 - Elsevier
Based on extensive studies on gonadotropin-releasing hormone (GnRH) it was assumed
that GnRH is the only hypothalamic neurohormone regulating gonadotropin release in …
that GnRH is the only hypothalamic neurohormone regulating gonadotropin release in …
Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior
K Tsutsui, T Ubuka, K Ukena - Frontiers in Neuroendocrinology, 2022 - Elsevier
The discovery of gonadotropin-inhibitory hormone (GnIH) in 2000 has led to a new research
era of reproductive neuroendocrinology because, for a long time, researchers believed that …
era of reproductive neuroendocrinology because, for a long time, researchers believed that …
Neuropeptidergic control of neurosteroids biosynthesis
T Ubuka, K Tsutsui - Frontiers in Neuroendocrinology, 2022 - Elsevier
Neurosteroids are steroids synthesized within the central nervous system either from
cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been …
cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been …
Gonadotrophin‐inhibitory hormone and its mammalian orthologue RF amide‐related peptide‐3: Discovery and functional implications for reproduction and stress
At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian
pituitary gonadotrophin secretion was identified and named gonadotrophin‐inhibitory …
pituitary gonadotrophin secretion was identified and named gonadotrophin‐inhibitory …
[HTML][HTML] Regulation of LH secretion by RFRP-3–From the hypothalamus to the pituitary
RFamide-related peptides (RFRPs) have long been identified as inhibitors of the
hypothalamus-pituitary-gonad axis in mammals. However, less progress has been made in …
hypothalamus-pituitary-gonad axis in mammals. However, less progress has been made in …
Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells transfected with their cognate receptor
B Wang, JA Paullada-Salmerón… - Frontiers in …, 2022 - frontiersin.org
Results of previous studies provided evidence for the existence of a functional gonadotropin-
inhibitory hormone (GnIH) system in the European sea bass, Dicentrarchus labrax, which …
inhibitory hormone (GnIH) system in the European sea bass, Dicentrarchus labrax, which …