The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets
Histamine and its receptors (H1R–H4R) play a crucial and significant role in the
development of various allergic diseases. Mast cells are multifunctional bone marrow …
development of various allergic diseases. Mast cells are multifunctional bone marrow …
Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens
Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially …
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially …
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
RL Thurmond, EW Gelfand, PJ Dunford - Nature reviews Drug …, 2008 - nature.com
Histamine has a key role in allergic inflammatory conditions. The inflammatory responses
resulting from the liberation of histamine have long been thought to be mediated by the …
resulting from the liberation of histamine have long been thought to be mediated by the …
Regulation of the immune response and inflammation by histamine and histamine receptors
Histamine is a biogenic amine with extensive effects on many cell types, including important
immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and …
immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and …
Histamine, histamine receptors and their role in immune pathology
The important roles of histamine in body physiology and various pathologic events have
been well established, whereas new and exciting findings are still being uncovered …
been well established, whereas new and exciting findings are still being uncovered …
Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
Various populations of regulatory T (Treg) cells have been shown to play a central role in the
maintenance of peripheral homeostasis and the establishment of controlled immune …
maintenance of peripheral homeostasis and the establishment of controlled immune …
Immunological mechanisms of allergen‐specific immunotherapy
M Jutel, CA Akdis - Allergy, 2011 - Wiley Online Library
To cite this article: Jutel M, Akdis CA. Immunological mechanisms of allergen‐specific
immunotherapy. Allergy 2011; 66: 725–732. Abstract The studies on the mechanisms of …
immunotherapy. Allergy 2011; 66: 725–732. Abstract The studies on the mechanisms of …
T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases
The identification of T regulatory (TReg) cells as key regulators of immunologic processes in
peripheral tolerance to allergens has opened an important era in the prevention and …
peripheral tolerance to allergens has opened an important era in the prevention and …
Histamine in the immune regulation of allergic inflammation
CA Akdis, K Blaser - Journal of allergy and clinical immunology, 2003 - Elsevier
Histamine was the first mediator implicated in mechanisms of allergy, asthma, and
anaphylactic shock because it has been discovered to mimic several features of these …
anaphylactic shock because it has been discovered to mimic several features of these …
Histamine receptors are hot in immunopharmacology
CA Akdis, FER Simons - European journal of pharmacology, 2006 - Elsevier
In addition to its well-characterized effects in the acute allergic inflammatory responses,
histamine has been demonstrated to affect chronic inflammation and regulate several …
histamine has been demonstrated to affect chronic inflammation and regulate several …