Novel therapies such as type 2 targeting biologics are emerging treatment options for
patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally associated with eosinophilic
tissue infiltration linked to type 2 inflammation and characterized by elevated levels of …

Background Eosinophilic inflammation has been implicated in the pathogenesis, severity,
and treatment responsiveness of chronic rhinosinusitis with nasal polyps (CRSwNP) …

Importance Dupilumab has demonstrated efficacy in patients with asthma and atopic
dermatitis, which are both type 2 helper T-cell–mediated diseases. Objective To assess …

Background Chronic rhinosinusitis with nasal polyps is frequently managed with endoscopic
sinus surgery (ESS). Prior studies describe individual clinical variables and eosinophil …

Background The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease
heterogeneity in patients with CRS remains poorly understood. This study aimed to identify …

Chronic rhinosinusitis can be differentiated into several phenotypes based on clinical
criteria; however, these phenotypes do not teach us much about the underlying inflammatory …

Chronic rhinosinusitis (CRS) occurs in> 10% of the adult population in Europe and the USA
and can be differentiated into CRS without nasal polyps and CRS with nasal polyps …

Background Tissue eosinophils are characteristic of inflammation in most but not all patients
with chronic rhinosinusitis with nasal polyps (CRSwNP) and may be useful for defining …

Chronic rhinosinusitis (CRS) often is characterized by an eosinophilic inflammatory pattern,
nowadays referred to as type 2 inflammation, although the mucosal inflammation is …