Conspectus The structural complexity of pharmaceuticals presents a significant challenge to
modern catalysis. Many published methods that work well on simple substrates often fail …

Conspectus The synthetic chemistry literature traditionally reports the scope of new methods
using simple, nonstandardized test molecules that have uncertain relevance in applied …

A multicomponent sulfonylarylation reaction via cobalt-catalyzed alkene difunctionalizations
with sulfonyl chlorides and OPiv-supported organozinc reagents was reported. Herein …

We herein report the preparation of solid and salt‐stabilized silylzinc pivalates from the
corresponding silyllithium reagents via transmetalation with Zn (OPiv) 2. These resulting …

The reaction of various organozinc pivalates with anthranils provides anilines derivatives,
which cyclize under acidic conditions providing condensed quinolines. Using alkenylzinc …

A cobalt‐catalyzed decarboxylative Negishi coupling reaction of redox‐active aliphatic
esters with organozinc reagents was developed. The method enabled efficient alkyl–aryl …

Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole
ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus …

The construction of Csp3–Csp3 bonds through Negishi-type reactions using alkylzinc
reagents as the pronucleophiles is of great importance for the synthesis of pharmaceuticals …

Installation of fluorine into pharmaceutically relevant molecules plays a vital role in their
properties of biology or medicinal chemistry. Direct difunctionalization of alkenes and 1, 3 …

Pharmaceutical discovery efforts rely on robust synthetic methods that rapidly access
diverse molecules. Cross-coupling reactions are the most widely used reactions, but these …