Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Cells use their cytoskeletons to move, polarise, divide and maintain organisation within
multicellular tissues. Actin is a highly conserved essential building block of the cytoskeleton …

Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by
controlling gene expression at the post-transcriptional level. Results We explore the …

Background: Prostate cancer (PCa) is a malignancy of the urinary system with a high
incidence, which is the second most common male cancer in the world. There are still huge …

Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that
regulate gene expression and are involved in physiological and pathological processes. In …

Retinoblastoma (RB) is the most common tumor of the eye in early childhood. Although
recent advances in conservative treatment have greatly improved the visual outcome, local …

Filamin A (FlnA) is a well-known actin cross-linking protein. It serves as a scaffold for over 90
binding partners and involves in multiple cell functions, of which cell migration and adhesion …

Chemoresistance is a leading cause of tumor relapse and treatment failure in colorectal
cancer (CRC) patients and is correlated with epithelial-mesenchymal transition (EMT). This …

Prostate cancer (PC) is the second leading cause of cancer related deaths in US men.
Androgen deprivation therapy (ADT) improves clinical outcome, but tumors often recur and …

The cellular response to hypoxia is regulated by hypoxia-inducible factor-1α and-2α (HIF-1α
and-2α). We have discovered that filamin A (FLNA), a large cytoskeletal actin-binding …