Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

Abnormally excessive growth results from perturbation of a complex interplay of genetic,
epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes …

Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …

Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately
one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions …

To support high proliferation, the majority of cancer cells undergo fundamental metabolic
changes such as increasing their glucose uptake and shifting to glycolysis for ATP …

Abstract Wilms' tumor (WT), the most common childhood kidney cancer, develops in
association with an underlying germline predisposition in up to 15% of cases. Germline …

Background Wilms' tumor is also called nephroblastoma and is the most common pediatric
renal cancer. Several genetic and epigenetic factors have been found to account for the …