In the relatively young but expanding field of irreversible kinase inhibitor drug discovery,
there are two main developments that are of central importance. First, the patients have …

The reversible phosphorylation of proteins ranks among the most important posttranslational
modifications that occur in the cell. In the last several decades, protein phosphorylation has …

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very
closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian …

Protein kinases share a number of highly conserved or invariant amino acid residues in their
catalytic domains, suggesting that these residues are necessary for kinase activity. In …

The epidermal growth factor (EGF) receptor is a tyrosine-specific protein kinase with
autophosphorylating activity1–4. A 300 amino acid-long region of the receptor's cytoplasmic …

Glycosphingolipids added exogenously to 3T3 cells in culture were shown to inhibit cell
growth, alter the membrane affinity to platelet-derived growth factor binding, and reduce …

Four mouse monoclonal antibodies specific for human epidermal growth factor (EGF)
receptors have been prepared using EGF receptor protein from human A431 epidermoid …

The receptor for epidermal growth factor (EGF) is a 170,000–180,000 molecular weight
single-chain glycoprotein of 1,186 amino acids1. Its sequence suggests that it has an …

The expression of receptors for epidermal growth factor (EGF-R) was determined in 29
samples of brain tumors from 22 patients. Primary gliogenous tumors, of various degrees of …

Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases
that mediate numerous cellular processes, including growth, proliferation, and …